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Moreover, ROS can directly target ETC complexes, especially complex I and complex III, causing electron leakage and amplifying ROS production, which further intensifies oxidative stress and mitochondrial dysfunction [26]

Supplementation of one of these compounds, -tocopherol, attacks free radicals to prevent lipid oxidation in retina and other body tissues.7,8

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Nijhout HF, Reed MC, Lam S-L, Gregory JF, Shane B, Ulrich CM: In silico experimentation with a model of hepatic mitochondrial folate metabolism

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