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While most of the current studies have been conducted in animal models, the results are impressive

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Analysis of selenoproteome characterized the functions and sequence of 6 glutathione peroxidases (GPXs) in mammals: cytosolic GPX (cGPX, GPX1), the first identified mammalian selenoprotein (6,15), phospholipid hydroperoxide GPX (PHGPX, GPX4) which was first described in 1982 and later verified as selenoprotein by sequencing (21,22), and other sequenced plasma GPX (pGPX, GPX3)(23), gastrointestinal GPX (GI-GPX, GPX2)(24) and, in humans, GPX6 which is restricted to the olfactory system (19)

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