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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 2% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Proposed mechanisms include: Enhancing cellular communication Supporting local growth factor expression Modulating nitric oxide pathways for circulation While promising, its important to note that human trials remain limited , and more research is needed before drawing definitive conclusions

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But the results did not match analysts' expectations, and Zealands shares tumbled in their wake