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Weight reduction with type 2 diabetes: In REDEFINE 2 the combination produced about 15.7% mean weight loss versus placebo over 68 weeks in adults with T2D [2]

Front Pharmacol 2020;11:585633

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Additionally, melatonin secretion patterns in NS workers were associated with differential methylation of key circadian genes, including RORA, MTNR1A, and PER3, suggesting a potential link between circadian disruption, epigenetic regulation, and cancer risk 196