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Severe Dehydration Signs of severe dehydration during pregnancy include dark urine, dizziness when standing, little to no urine production, and persistent thirst

Obeid et al., 2015)

The intranasal route allows perineural transport via the olfactory nerves, reaching the brain in less than 5 minutes

They pretreated subjects with n-acetyl-cysteine infusion (150 mg/kg) or a 5% dextrose placebo while undergoing an extended fatiguing bout of electrical stimulation of the ankle dorsiflexors