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Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness

Raygan F, Ostadmohammadi V, Bahmani F, Reiter RJ, Asemi Z

The protocols in use come from extrapolation of animal data, pharmacokinetic studies, and clinical experience from practitioners who have incorporated the compound into their practice

Mice were anesthetized with isoflurane and fixed in prone position

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