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doi: 10.3389/fendo.2026.1788698 Received 15 January 2026 Revised 30 January 2026 Accepted 13 February 2026 Published 03 March 2026 Volume 17 - 2026 Edited by Ploutarchos Tzoulis, University College London, United Kingdom Reviewed by Lai San Tham, Eli Lilly, United States Updates Copyright 2026 Alhazmi and le Roux

Droxidopa can also cross the blood brain barrier, and hypothetically may be useful in patients with various CNS disorders