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Important clinical note: Prescribers should counsel patients that compounded preparations are not FDA-approved, that quality can vary between pharmacies, and that the evidence base for specific compounded formulations is more limited than for FDA-approved products

Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids

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