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For Helicobacter pylori -associated gastric pathology, VacA channel blockers offer a promising approach to prevent toxin-mediated mitochondrial disruption ( In addition, the polyphenol epigallocatechin gallate (EGCG) has been shown to suppress cGAS activation, thereby mitigating Carbapenem-resistant Acinetobacter baumannii -induced inflammation and mitochondrial dysfunction, highlighting its potential as a host-directed immunomodulator (Yang et al., 2024)

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After five washes with TBST (0.05% Tween), the membranes were incubated with the secondary antibody for 1 h at room temperature

However, even when large oral doses are administered, most of the absorbed glutathione remain within the gut luminal cells and only small and transient increase of glutathione occurs in the circulation