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That reaction is more common than most people admit

When the mice were fed a diet deficient in choline, that is, lacking precursors required for DMG production, they failed to gain weight after smoking cessation. The second bioactive metabolite, acetylglycine, or ACG, followed a mirror-image pattern to that of DMG: Its levels were reduced during active exposure to smoke and after the exposure stopped, they increased following antibiotic treatment

could be blamed on smoking

The Los Angeles Times