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Untreated Vitamin B12 deficiency can lead to severe anemia, nerve damage, cognitive decline, and irreversible neurological impairment

Fine LM, Bernstein JA

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Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects

[2] [3] Taking berberine with food may reduce gastrointestinal side effects