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For instance, curcumin significantly reduced histopathological damage and improved general symptoms in experimental colitis, accompanied by increased the expression of Treg cells and decreased the expression of Th17 cells as well as increased the expression of anti-inflammatory cytokines such as IL-10 and decreased the expression of proinflammatory cytokines such as IL-17A, IL-1, IL-6, IL-33, CCL-2, IFN-, and TNF- [264, 266, 267]

Effects: Improved skin condition: Reduced pigmentation, increased skin tone and elasticity, stimulation of collagen synthesis

2.1.1 BioUnion BioUnion filler is a novel bioactive glass powder (Xia et al., 2025), that addresses the issue of declining fluoride release over time observed in traditional glass ionomer cements (GICs) ( 2 ), zinc oxide (ZnO), calcium oxide (CaO), and a fluoride compound

This more curated approach often aligns with tighter quality control standards and stronger batch-level documentation