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Most studies focus on biochemical markers (e.g., oxidative stress parameters, inflammatory cytokines) and histological assessments of ovarian tissue

Regarding study status, 120 studies (45.8%) were reported as completed, with a median study duration of 2.0 years (IQR 0.932.82)

In this regard, evidence has been provided that a mutated p53 form can sustain Nrf2-mediated antioxidant response to allow cancer cell adaptation to the tumour-typical increased ROS levels [35] and to confer chemoresistance [36]

Cautionary voices in the medical community highlight that until we have more data, BPC-157 should be considered an experimental substance