Toxins, including benzene (a chemical sometimes used in manufacturing and chemical synthesis), pesticides, and arsenic Chemotherapy and radiation therapy for cancer treatment Various infectious diseases, including hepatitis, HIV, and Epstein-Barr virus (a type of herpesvirus) Autoimmune disorders such as lupus and rheumatoid arthritis Pregnancy Certain drugs, including some antibiotics, immunosuppressants, and some nonsteroidal anti-inflammatory drugs (NSAIDs) Fanconi anemia ShwachmanDiamond syndrome Ataxia-pancytopenia syndrome Over time, severe heart issues may develop, such as arrhythmia (irregular heartbeat), angina, enlarged heart, and heart failure
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SLC7A11 acts as an exchange transporter to import cystine in exchange for glutamate, whereas SLC3A2 functions as a molecular chaperone to maintain SLC7A11 protein stability and membrane localization [10]