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Most patients find it tolerable because the needles are very fine and the injections shallow

The studied dosage for AOD 9604 is 300 mcg/day

But those trials were small (approximately 300 subjects total across phases), short (up to 24 weeks), and used a route of administration that likely delivered minimal systemic exposure

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Who Should Talk to a Doctor Before Starting Anyone with thyroid disease, pernicious anemia, or a condition affecting the digestive system should have a proper conversation with a doctor or naturopathic doctor before starting B12 injections, since the underlying condition may need separate treatment alongside supplementation