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The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate

B12 testing is often performed indiscriminately as part of routine screening and can lead to unnecessary diagnostic and management quandaries

Theoretically yes, but stacking introduces complexity without clear additive benefit unless your hypothesis specifically tests synergy between NNMT inhibition and direct lipolytic stimulation

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