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NMNAT2 is a druggable target to drive neuronal NAD production
2012;34(10):12817 Veringa SJE, Nanayakkara PWB, van Ittersum FJ
This steadier drug level also means that GI side effects, when they occur, tend to be milder with sublingual dosing
Prodrome During prodrome, early, flu-like symptoms occur, including: a fever of 100.4F (38C) or above headache anxiety feeling generally unwell sore throat and a cough nausea and vomiting discomfort at the site of the bite Acute neurologic period During this stage, neurologic symptoms develop, including: confusion and aggression partial paralysis involuntary muscle twitching rigid neck muscles convulsions hyperventilation and difficulty breathing hypersalivation, or producing a lot of saliva frothing at the mouth fear of water, or hydrophobia hallucinations, nightmares, and insomnia priapism, or permanent erection, in males photophobia, or a fear of light Toward the end of this phase, breathing becomes rapid and inconsistent
