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Clinical trial data from Retatrutide research and from comparable GLP-1 compound trials consistently shows that participants maintaining 80g+ of protein daily preserved lean mass significantly better than those whose protein intake dropped under caloric suppression

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[82] However, evidence for age-associated NAD + decline in humans remains inconsistent and may depend on the tissue or biological compartment examined, with recent studies reporting stable whole-blood NAD + levels across age and lifestyle interventions