Table S4
Such alterations may result in dysfunction or symptoms involving high energy-consuming organs such as the brain, liver, heart, and skeletal muscles (64)
Recent studies have explored small-molecule inducers, selenium-based compounds, and targeted nanodelivery approaches to restore GPX4 function or mimic its antioxidant capacity in ferroptosis-prone diseases, with therapeutic implications for OA and beyond ( In summary, GPX4 acts not only as a terminal antioxidant enzyme but also as a hub that integrates transcriptional, post-transcriptional, and nutritional cues
For more information on iodine deficiency, which is now accepted as the most common cause of preventable brain damage in the world, see the article on Iodine
lk etapta yorgunluk ve baklk zayfl dikkat ekerken, ilerleyen dnemlerde karacier fonksiyon bozukluklar, sinir sistemi sorunlar ve kronik inflamasyon gibi tablolar geliebilir