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References Garcia-Alonso L, Handfield LF, Roberts K, Nikolakopoulou K, Fernando RC, Gardner L, Woodhams B, Arutyunyan A, Polanski K, Hoo R, Sancho-Serra C, Li T, Kwakwa K, Tuck E, Lorenzi V, Massalha H, Prete M, Kleshchevnikov V, Tarkowska A, Porter T, Mazzeo CI, van Dongen S, Dabrowska M, Vaskivskyi V, Mahbubani KT, Park JE, Jimenez-Linan M, Campos L, Kiselev VY, Lindskog C, Ayuk P, Prigmore E, Stratton MR, Saeb-Parsy K, Moffett A, Moore L, Bayraktar OA, Teichmann SA, Turco MY (2021) Vento-Tormo, mapping the Temporal and Spatial dynamics of the human endometrium in vivo and in vitro

10.1016/j.advnut.2023.09.002 37

FOXO4-DRI works by disrupting the specific protein-protein interaction that keeps senescent cells alive

The study began by collecting blood samples from the jugular veins of fourth-month old, male Sprague-Dawley rats

Lower concentrations (0.1 percent or less) show activity in lab settings but lack convincing human clinical data