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4 Application of DDS in gout and hyperuricemia 4.1 Introduction to DDSs and its classification in gout/hyperuricemia management DDSs represent engineered platforms designed to optimize drug pharmacokinetics and biodistribution through advanced carrier technologies (e.g., nanoparticles, colloidal systems, and polymers)

Common behavior changes include: Avoiding social situations Missing work, school, or appointments Repeating certain actions to feel safe Asking for reassurance often Avoiding driving, crowds, or public places Struggling with daily responsibilities Avoiding fear may help for a short time, but it can make anxiety stronger over time

Front Med (Lausanne) (2020) 7:124