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In erythroleukemia K562 cells, in addition to the above identified NRF2 binding ARE motif, there is also a strong association of active histone codes (such as H3K4Me3, H3K9Ac, H3K27Ac, H3K79Me2) upstream of the transcription start site (Supplementary Fig

doi: 10.3389/fphar.2026.1740609 Received 06 November 2025 Revised 03 February 2026 Accepted 11 February 2026 Published 24 February 2026 Volume 17 - 2026 Edited by Ziyi Wang, Johns Hopkins University, United States Reviewed by Xue Xiaoyong, Beijing University of Chinese Medicine, China Yatan Li, Xinjiang Medical University, China Updates Copyright 2026 Pang, Jiang, Ge, Huang, Rao, Wang, Zhou, Lyu, Wang and Tan

The onset of disease, its course, and the possibility of recovery largely depend on the mental state of a person