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When cells become resistant to insulin a condition known as insulin resistance the pancreas compensates by producing more insulin

Braz J Med Biol Res 49(12):e5826 Dokken BB, La Bonte LR, Davis-Gorman G, Teachey MK, Seaver N, McDonagh PF (2011) Glucagon-like peptide-1 (GLP-1), immediately prior to reperfusion, decreases neutrophil activation and reduces myocardial infarct size in rodents

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However, PPAR was downregulated in patients with NASH compared to patients with steatosis and healthy controls [75, 86], and the expression of PPAR decreased with increasing NAFLD activity score and fibrosis stage [86]

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