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It is important to note that while prednisone can provide significant relief from symptoms, it may also come with a range of side effects, especially with long-term use

ROC analysis of adduct levels in serum from patients known to have APAP hepatotoxicity showed that an APAP protein adduct level 1.1 nmol/mL had a high sensitivity and specificity (96.8 and 95.0 %, respectively) for patients with APAP overdose and ALT levels above 1000 IU/L

These endotypes are often broadly grouped into eosinophilic T helper 2 inflammation (T2 high) and non-eosinophilic (T2 low) asthma

USA 115 , E12363E12369 (2018)

The therapeutic window appears quite wide, with most users experiencing benefits without significant side effects across a range of doses