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Dimethyl sulfoxide (DMSO) was used as the solvent for each compound before dilution with the medium

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Gradual Dose Escalation Gradual dose escalation proceeds with: Weeks 1-4: 1 mg once daily Weeks 5-8: 2 mg once daily Thereafter: Adjustment based on individual response and goals Dosing Frequency Options Dosing frequency most commonly involves once daily administration (morning or evening), with alternative protocols using 2-3 times per week at 2 mg per injection