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Yang J, Wang X, Huang B, Liu R, Xiong H, Ye F, Zeng C, Fu X, Li L

PMID: 22682224 | doi:10.1016/j.cmet.2012.04.022 Yoshino J et al

Let the water run down the inside wall of the vial

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The specific mechanism may also be by activating VEGF-A / VEGFR1 -mediated AKT and p38/MAPK signaling pathways to upregulate downstream eNOS expression, which may increase the NO product synthesis, thus promote angiogenesis of gastric mucosa and also interact with endoplasmic reticulum (ER) stress