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The Muscle Preservation Challenge Significant weight loss inevitably involves some degree of lean mass reduction

\n\n\n\n Large-scale human clinical trials are currently lacking

The effective blood-brain barrier mechanism impeding the transport of monoamines has been attributed to both the presence of tight junctions cementing adjacent endothelial cells of the cerebral capillary walls, along with high concentrations of dopa decarboxylase and monoamine oxidase (MAO) in the cerebral capillary endothelium (Bertler et al, 1966

Differentiating between these entities may have important implications for treatment strategy

Gradual titration (dose escalation) leads to better tolerability