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In T cells, however, arginine restriction causes repressive histone methylation and globally compact chromatin and results in low expression of argininosuccinate synthetase 1

Based on these results, scientists at Tokushima University Hospital and Suzuka University of Medical Science, in Japan, conducted a long-term Phase 2/3 clinical trial (NCT00444613) to evaluate the efficacy and safety of ultra-high-dose methylcobalamin treatment for ALS