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Moreover, royal jelly acid regulated TGF-1, SNAI1, GSK-3, E-cadherin, N-cadherin, and vimentin, inhibiting lung cancer cell migration ( In HCT-116 and SW-480 human colon cancer cells, royal jelly acid has displayed remarkable migratory and invasive effects by inducing significant suppression of promigratory/proinvasive markers, N-cadherin, vimentin and Snail on protein and gene levels (Yang, et al., 2018)

The rationale behind combining them is rooted in cellular metabolism

J Clin Gastroenterol 38:S86S90 Uttra AM, Shahzad M, Shabbir A, Jahan S (2018) Ephedra gerardiana aqueous ethanolic extract and fractions attenuate Freund Complete Adjuvant induced arthritis in Sprague Dawley rats by downregulating PGE2, COX2, IL-1, IL-6, TNF-, NF-kB and upregulating IL-4 and IL-10

Jul 2008;15(3):28496