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ROS-induced NO inactivation can impair vascular endothelial function, contributing to various pathologies like atherosclerosis, hypertension, cardiovascular disease, and central nervous system disorders (27, 28)

Additionally, VDC886, a hemiasterlin analog (KT886) conjugated with the refined malaria protein VAR2, has shown anti-cancer activity in various types of cancer, including strong cytotoxicity to C3 human and B16 murine melanoma cells [90]

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The category as a whole is where the strong evidence lives

Mechanistically, circRNF19A-490aa interacted with HSP90AA1, thereby enhancing AR activity and facilitating activation of Akt/mTOR and PLK1 signaling