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Low-dose naltrexone (LDN) has emerged as one of the most promising agents in this area, working through glial cell modulation to reduce neuroinflammation and through toll-like receptor pathways to quiet abnormal immune activation

[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Dantzer R., OConnor J.C., Freund G.G., Johnson R.W., Kelley K.W

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For instance, a study by Harding et al

[634] Second, this measure meets the conditions for measure removal factor six: there is an available measure that is more strongly associated with desired patient functional outcomes