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Hexarelin, a synthetic growth hormone releasing peptide, shows no desensitization effect on GH secretion in humans after 8 days of administration. Journal of Endocrinological Investigation (Contrasting acute vs chronic models)

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This finding is uniformly pathologic, is more common in men than women 69 and, when present, manifests with osteopaenia and fractures in up to 47% of patients 20

10.1007/s10620-008-0332-9 130 SkorjanecS.KokotA.DrmicD.RadicB.SeverM.KlicekR.et al (2015)

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