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For this FY 2024 proposed rule, to comply with the requirement that MS-DRG reclassification and recalibration of the relative weights be budget neutral for the standardized amount and the hospital-specific rates, we used FY 2022 discharge data to simulate payments and compared the following: Aggregate payments using the FY 2023 labor-related share percentages, the FY 2023 relative weights, and the FY 2023 pre-reclassified wage data, and applied the proposed proxy FY 2024 hospital readmissions payment adjustments and proposed proxy FY 2024 hospital VBP payment adjustments

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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This trial the highest dose of retatrutide (12 mg) led to 16.9% weight loss (vs 3.0% with placebo) at 36 weeks