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Triple-agonist: GLP-1 + GIP + glucagon receptors

The most frequently reported include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation

However, in a study performed on male mice lacking the gene that encodes for NO synthase 1, these mice were found to have abnormal anxiety levels compared to their counterparts (166, 167)

These include mutations in genes such as: SNCA Alpha-synuclein gene PRKN Parkin RBR E3 Ubiquitin Protein Ligase PINK1 Gene PARK6 DJ-1 and PARK7 Gene LRRK2 It is believed that mutations in these genes can cause dysfunction and eventual death of dopamine-producing neurons through various mechanisms, including protein aggregation, mitochondrial dysfunction, and oxidative stress

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