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PMID: 37331409 Toxicol Res (Camb) Tamoxifen induced hepatic steatosis in high-fat feeding rats through SIRT1-Foxo1 suppression and LXR-SREBP1c activation

Autophagy, a conserved cellular process through which cells degrade their own components (e.g., organelles and proteins) via lysosomal activity to balance energy for survival [86], is linked to hepatic steatosis through impaired autophagic flux, whereas activating lysosomal autophagy can promote the clearance of hepatic lipid droplets, highlighting its potential in treating NAFLD/MAFLD [87]

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Semaglutide delivered via subcutaneous injectiontypically into the abdomen, thigh, or upper armrequires the needle to penetrate skin layers and fatty tissue

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