In the liver compartment the metabolism of acetaminophen includes sulfation, glucoronidation, conjugation with glutathione, production of the toxic metabolite, and liver damage, taking biochemical parameters from the literature whenever possible
Other Sulfonamide-containing drugs: a) Diuretics: Thiazide diuretics (e.g., Hydrochlorothiazide, Chlorthalidone) Loop diuretics (e.g., Furosemide, Bumetanide) b) Sulfonylureas (Diabetes medications): Glipizide Glyburide Glimepiride c) Carbonic Anhydrase Inhibitors: Acetazolamide (used in glaucoma, altitude sickness) Dorzolamide, Brinzolamide (ophthalmic drugs for glaucoma) d) Anticonvulsants: Zonisamide Topiramate 3
Its used to measure our level of intoxication for legal or medical purposes
However, we also wanted to make sure that the fish model results (figure 2.4) accurately represent what happens with human crystallin proteins, so we tested the effects of H2O2 using human CRYAB as well
10.1016/j.regpep.2009.11.012 95 TurkovicB.SikiricP.SeiwerthS.MiseS.AnicT.PetekM.et al (2004)