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Eddie Chang, MD, a neurosurgeon and Chair of the Department of Neurological Surgery at the University of California, San Francisco (UCSF)

Its a small-molecule research compound investigated in studies involving Nicotinamide N-Methyltransferase (NNMT)

The activity of RFC-mediated folate transport is highest for reduced folates (hence the name) such as 5-methyl-THF with very low affinity for folic acid

The clinical data referenced in this article are from the published research available at the time of writing

Frequently Asked Questions Pigmentation is the decolorization of the skin determined by a pigment called melanin