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PMID: 2415780

Additionally, the heightened production of pro-inflammatory cytokines and chemokines from senescent cells exacerbates the inflammatory load and interferes with the aging process in CKD

Activation of the MAPK/ERK pathway phosphorylates the RRM2 Ser20 site, enhancing its stability and promoting drug resistance (Zhan et al., 2021)

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Drug Dosing Disclaimer: We are only able to provide doses for medications that are FDA approved for use in cats and only as the label guidelines dictate