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Adaptive immune responses, mediated by T and B cells, produce autoantibodies, including anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF), forming immune complexes that exacerbate synovial damage (13)

Without adequate fiber, hydration, and elimination, some of these compounds may be reabsorbed through what is known as enterohepatic recirculation

Lai ZW, Hanczko R, Bonilla E, et al

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