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1 ,2 About the REDEFINE 1 trial REDEFINE 1 was a double-blind, placebo-and active-controlled 68-week efficacy and safety phase 3 trial of once-weekly CagriSema (cagrilintide 2.4 mg and semaglutide 2.4 mg), cagrilintide 2.4 mg monotherapy and semaglutide 2.4 mg monotherapy versus placebo in 3,417 adults with obesity (BMI 30 kg/m 2 ), or overweight (BMI 27 kg/m 2 ) with one or more obesity-related comorbidities, and without type 2 diabetes

However, some comparative studies in animals suggest that oral ingestion of the peptide can also have systemic effects