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All of these results prove that Hsa21 overexpression may contribute to changes in genes from other chromosomes, causing different phenotypes associated with the CHD in the DS context

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Hempel M, Cremer K, Ockeloen CW, Lichtenbelt KD, Herkert JC, Denecke J, Haack TB et al (2015) De Novo Mutations in CHAMP1 Cause Intellectual Disability with Severe Speech Impairment