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Description

P., Krutchen, A

10.1038/ncomms5196 199 WeissJ

When conjugated with a hemiasterlin analog (KT886) to form VDC886, it exhibited strong in vitro cytotoxicity against 33 cancerous cell lines which include melanoma (C3 human and B16 murine cell lines), glioma, human mammary cancer (4T1 and MDA-MB-231 cancerous cell lines), lymphoma (MyLa2059 T-cell line), and human colon cancer cell line (Colo 205) at inhibitory concentrations 50 (IC50) between 0.2 pM to 30 nM