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Moreover, ferroptosis plays an important role in the pathogenesis of liver diseases, with studies showing that acetaminophen (APAP)-induced ALF is related to ferroptosis[8]

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In the case of iron metabolic disorder, the low expression of FTH1 and the overexpression of TFR1 often lead to the excessive accumulation of Fe 2+ ions, which induce the production and accumulation of a large amount of ROS through Fenton reaction and eventually promote cell ferroptosis (Daher and Karim, 2017)