This combination of factors, in turn, causes a hypoxic microenvironment and mitochondrial dysfunction (McGarry et al., 2018), promoting inflammation and oxidative damage by increasing the production of ROS (McGarry et al., 2018)
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The effects produced by interfering with glycolysis in OA still warrant more in-depth investigation, as is the case in cancer therapy, where inhibition of glycolysis can reduce tumor progression while causing a variety of side effects
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B., Grimm, Lena L., Low, Chek -Fong, Morgenstern, David, Herzig, Volker, Zobel-Thropp, Pamela, Pineda, Sandy Steffany, Habib, Rosaline, Dziemborowicz, Slawomir, Fry, Bryan G., Nicholson, Graham M., Binford, Greta J., Mobli, Mehdi and King, Glenn F