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Nutrients (2022) 14:1727

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Within endosomes, zinc contributes to tethering and fusion by stabilizing zinc-dependent tethering factors, such as the zinc finger protein EEA1, which facilitates SNARE complex assembly and ensures efficient cargo sorting and receptor recycling 99,100

5 CR reduces fasting insulin levels and improves insulin sensitivity in overweight individuals, whereby these effects may be more pronounced with regular IF compared with chronic CR