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Role of transcription factors in T cell exhaustion The expression of the TOX transcription factor is key to the process of T cell exhaustion, which is activated by the TCR pathway in response to prolonged antigenic stimulation and is induced by calmodulin phosphatase-mediated activation of NFAT [64, 65]

Due to sperms abundance of membrane polyunsaturated fatty acids (PUFAs) and their own innate capacity to generate reactive oxygen species (ROS) (via abnormally shaped sperm morphology), human sperm are highly susceptible to oxidative stress (inflammation)

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Salicylic acid analogues as chemical exchange saturation transfer MRI contrast agents for the assessment of brain perfusion territory and blood-brain barrier opening after intra-arterial infusion

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