[DOI] [PubMed] [Google Scholar] 13.Xu G, Sztalryd C, Londos C
Vitamin B 12is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis
At the molecular level, 5-amino-1MQ functions as a competitive inhibitor of NNMT, demonstrating remarkable potency with an IC of 1.2 0.1 M under standard assay conditions (50 M SAM, 100 M nicotinic acid). This represents a dramatic 10-fold improvement over the parent compound 1-methylquinolinium, achieved through strategic amino group substitution that enhances binding affinity to the NNMT active site. The compound's mechanism centers on preventing the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), thereby preserving nicotinamide for recycling back to NAD+ through the salvage pathway. This intervention effectively blocks what researchers have termed the "NNMT metabolic drain" a process that simultaneously depletes NAD+ precursors and consumes cellular methylation capacity
Dosage--This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY
If you're still unsure, the best way to decide which method is right for you is to talk to your doctor
