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A comparison between the apo- and Cu I -bound states suggests a mechanism of allosteric connectivity where the metal binding event induces a kink in the 2 helix, which leads to a rearrangement of surface electrostatic potential distribution, thus driving DNA dissociation and transcriptional derepression of Cu I -resistance genes

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Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis

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