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S protein-neutralizing antibodies nAbs targeting the SARS-CoV-2 S trimer have shown protection from viral infection in animal models and are being evaluated as therapeutics in humans

Cigarette smoke contains thousands of chemicals and oxidants that can induce oxidative stress and modify biomolecules, including proteins, lipids, nucleic acids, or carbohydrates, thus affecting lung physiology and tissue homeostasis ( in vitro was attenuated due to its conformational changes

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Despite unchanged ILC2 numbers, melatonin significantly reduced BALF IL-5 and IL-13 levels ( Figures 1M, N ), suggesting functional suppression of type 2 cytokine production rather than depletion of ILC2s ( Figures 1K, L )