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Notably, the compound is stable across a wide pH range and fully soluble in aqueous media, unusual properties for a peptide of this size that are attributed to its high proportion of proline and charged residues

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2020;12(2):e6976

We followed up to ask whether the journal was aware of the March 2018 report from the university

Previously, biopsies of doxycycline-induced hyperpigmentation revealed increased melanisation in the basal layers of the epidermal keratinocytes, 4,5 suggesting activation of melanocytes either by the tetracycline derivative itself or by another co-stimulus